Positions and Honors

1966-1967         Research Associate, Naval Ordinance Laboratory, Corona, CA

1971-1972         Research Associate, Coordinated Science Department, University of Illinois, Urbana, IL

1972-1976         Software Engineer at Boeing Aerospace Corporation, Seattle, WA

1977-1982         Research Fellow, Department of Anesthesiology, University of Washington School of Medicine, Seattle WA

1983-1985         Acting Assistant Professor, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA

1985-1990         Research Scientist, Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA

1990-1/1995      Staff Scientist, Fred Hutchinson Cancer Research Center, Seattle, WA

1991/1995-99    Scientific Programmer, Department of Cardiology, University of Washington, Seattle, WA

Consultant; International Association for the Study of Pain, Seattle, WA

2001-Present     Research Assistant Professor, Dept. of Anesthesiology, Univ. of Utah, Salt Lake City, UT

Publications

Pollack GH, Delay MJ, Ishide N, Jacobson RC: The control of tension and shortening in cardiac and skeletal muscle. Ann Biomed Eng 8:405-413, 1980.

Delay MJ, Ishide N, Jacobson RC, Pollack GH, Tirosh R: Stepwise sarcomere shortening: Analysis by high-speed cinemicrography. Science 213:1523-1525, 1981.

Myers J, Tirosh R, Jacobson RC, Pollack GH: Phase-locked loop measurement of sarcomere length with high time resolution. IEEE Trans Biomed Eng 6:463-466, 1982.

Jacobson RC, Tirosh R, Delay MJ, Pollack GH: Quantized nature of sarcomere shortening steps. J Muscle Res Cell Motil Oct. 1983.

Pollack GH, Vassallo CV, Jacobson RC, Iwazumi T, Delay MJ: Discrete nature of sarcomere shortening in striated muscle. In: Sugi H, Pollack GH, (Eds): Cross-bridge Mechanisms in Muscle Contraction. Tokyo, University of Tokyo Press, 1983, pp 23-40.

Pollack GH, Tirosh R, Brozovich FV, Lacktis JW, Jacobson RC, Tameyasu T: Stepwise shortening: Evidence and implications. In: Sugi H, Pollack GH (Eds): Contractile Mechanisms in Muscle, Vol II: Mechanics, Energetics and Molecular Models. New York, Plenum Press, 1983.

Chapman CR, Jacobson, RC: Assessment of analgesic states: Can evoked potentials play a role? In: Bromm B (Ed): Pain Measurement in Man. Amsterdam, Elsevier, 1984, pp 233-255.

Jacobson RC, Chapman CR, Gerlach R: Stimulus intensity and interstimulus interval effects on pain-related cerebral potentials. Electroencephalogr Clin Neurophysiol 62:352-363, 1985.

Chapman CR, Gerlach R, Jacobson RC, Buffington V, Kaufman E: Comparison of short latency trigeminal evoked potentials elicited by painful dental stimulation. Electroencephalogr Clin Neurophysiol 65:20-26, 1986.

Hill HF, Mackie AM, Jacobson RC: Infusion-based patient-controlled analgesia systems. In: Ferrante, Ostheimer, Covino (Eds): Patient-Controlled Analgesia. Cambridge, Blackwell Scientific Publications, 1990.

Hill HF, Saeger L, Bjurstrom R, Donaldson G, Chapman CR, Jacobson RC: Steady-state infusions of opioids in human volunteers. I. Pharmacokinetic tailoring. Pain 43:57-67, 1990.

Hill HF, Jacobson RC, Coda B, Mackie AM: A computer-based system for controlling plasma opioid concentration according to patient need for analgesia. Clin Pharmacokinet 20:319-330, 1991.

Hill HF, Coda BA, Chapman CR, Hunt E, Mackie AM, Vincent S, Jacobson RC: Tailored infusions of morphine and alfentanil: Cognitive and motor function effects. Clin Pharmacol Therap, 1991.

Hill HF, Mackie AM, Coda BA, Schaffer R, Jacobson RC, Benedetti C: Evaluation of the accuracy of a pharmacokinetically-based patient controlled analgesia system. Eur J Clin Pharmacol 43:67-75, 1992.

Chapman CR, Donaldson GW, Jacobson RC: Measurement of acute pain states. In: Turk DC, Melzack R (Eds): Handbook of Pain Assessment. New York, Guilford Press, 1992, pp 332-343.

Coda BA, Hill HF, Schaffer RL, Luger TJ, Jacobson RC: Enhancement of morphine analgesia by fenfluramine in subjects receiving tailored opioid infusions. Pain 52:85-91, 1993.

Coda BA, Hill HF, Hunt EB, Kerr EB, Jacobson RC, Chapman CR: Cognitive and motor function impairments during continuous opioid analgesic infusions. Human Psycopharmacology 8:383-400, 1993.

Pavlin J, Coda B, Shen DD, Tschanz J, Nguyen Q, Schaffer R, Donaldson G, Jacobson RC, Chapman CR: Effects of combining propofol and alfentanil on ventilation, analgesia, sedation and emesis in human volunteers. Anesthesiology 84:23-37, 1996.

Chapman CR, Donaldson GW, Jacobson RC, Hautman B (1997): Differences among patients in opioid self-administration during bone marrow transplantation. Pain 71:213-223.

Coda B, Tanaka A, Jacobson RC, Donaldson G, Chapman CR (1997): Hydromorphone analgesia after intravenous bolus administration. Pain 71:41-48.

Chapman CR, Oka S, Bradshaw D, Jacobson RC, Donaldson G (1999): Phasic pupil dilation response to noxious stimulation in normal volunteers: Relationship to brain evoked potentials and pain report. Psychophysiology 36:44-52.

Oka S, Chapman CR, Jacobson RC (2000): Phasic pupil dilation response to noxious stimulation: effects of conduction distance, sex and age. J Psychophysiol 14:97-105.

Chapman CR, Nakamura Y, Donaldson GW, Jacobson RC, Bradshaw DH, Flores LY, Chapman CN (2001): Sensory and affective dimensions of phasic pain are indistinguishable in the self-report and psychophysiology of normal laboratory subjects. The Journal of Pain, Vol. 2, No 5, pp 279-294

Chapman CR, Donaldson GW, Nakamura Y, Jacobson RC, Bradshaw DH, Gavrin JA (in press): Psychophysiological causal model of pain report validity. The Journal of Pain.

Donaldson DW, Chapman CR, Nakamura Y, Bradshaw DH, Jacobson RC, Chapman CN (in press): Pain and the defense response: structural equation modeling reveals coordinated psychophysiological response to increasing painful stimulation. Pain.

Research Support

Ongoing

R01AR046303-03 Okifuji (PI)                                          9-11-2000 – 7/31/05

NIAMSD

Sex Hormones, Stress, and Pain in Fibromyalgia

The primary goals of this project are to test several components of a conceptual model hypothesizing how hormonal and stress factors are related to fibromyalgia syndrome, a chronic musculoskelatal pain disorder.

Role: Co-Investigator

Ongoing

RO1CA74249-04 Chapman (PI)                           2/01/2000-1/31/02

NIH/NCI                                                           

Pain and the Defense Response

The major goals of this project are to investigate the emotional dimension of pain in the human studies laboratory, to identify patterns of psychophsyiological response associated with pain and to relate these patterns to the classically defined defense response, and to explore and quantify individual differences in sensory and emotional dimensions of pain.

Role: Co-Investigator

Ongoing

R21 AR46077 Okifuji (PI)                                              03/01/99 -- 02/28/02

NIH NIAMS                                            

Autonomic Stress-Reactivity in Fibromyalgia

The aims of the project are to 1) Examine the presence of blunted sympathetic reactivity in FMS patients; 2) determine whether FMS is related to increased susceptibility to the development of orththostatic intolerance; 3) examine whether stress-induced analgesia is minimized in FMS.

Role: Co-Investigator

Completed:

RO1CA 74269-04 Chapman (PI)                           4/01/97 – 3/31/2001

NIH/NCI                                                           

Pain Measurement in Bone Marrow Transplantation

The specific aims of this study are: 1. implement an interactive, multidimensional, portable electronic tool for pain interviews with BMT patients and compare its performance to that of a standard pain assessment procedure involving real time physicians data entry. 2. Develop and refine new pain scaling methods derived from the fields of psychophysics and psychometrics that take advantage of available tissue trauma scores. 3. Compare the quality of pain measurement achieved with the two new methods and the standard raw score method, determining which approach permits the most accurate forecasting of future pain from past pain. 4. Clarify the nature and extent of individual differences in oral mucositis pain in the bone marrow transplant setting.         

Role: Co-Investigator