Table 12. Intraspinal drug delivery systems

System Advantages Disadvantages
Percutaneous
temporary catheter
Used extensively both
intraoperative and
postoperatively. Useful
when prognosis is limited (<1 month).
Mechanical problems
include catheter
dislodgment, kinking, or
migration.
Permanent silicone-
rubber epidural
Catheter implantation is
a minor procedure.
Dislodgment and
infection less common
than with temporary
catheters. Can deliver
bolus injections,
continuous infusions, or
PCA (with or without
continuous delivery).
Subcutaneous implanted
injection port
Increased stability, less risk of
dislodgment. Can deliver bolus
injections or continuous infusions
(with or without PCA).
Implantation more invasive
than external catheters. Approved
only for epidural
placement in U.S.
Potential for infection
increases with frequent
injections.
Subcutaneous reservoir Potentially, reduced infection
in comparison to external
system.
Difficult to access, and
fibrosis may occur after
repeated injection.
Implanted pumps
(continuous and
programmable)
Potentially, decreased
risk of infection.
Need for more extensive
operative procedure.
Need for specialized
equipment with
programmable systems.

Related Chunks

Transdermal

Nasal

Intravenous or Subcutaneous

Intraspinal

Intraventricular

Adjuvant Drugs

General comments and cautions regarding the use of opioid analgesics

Neuraxial Opioid Infusion

Index